Portal de Periódicos da CAPES

BCX-1812 (RWJ-270201): Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design

2000; American Chemical Society; Volume: 43; Issue: 19 Linguagem: Inglês

10.1021/jm0002679

1520-4804

Y.S. Babu, Pooran Chand, Shanta Bantia, Pravin L. Kotian, Ali Dehghani, Yahya El-Kattan, Tsu‐Hsing Lin, Tracy L. Hutchison, Arthur J. Elliott, Cynthia Parker, Sandya L. Ananth, LaShun L. Horn, Graeme Laver, John A. Montgomery,

Chemical Synthesis and Analysis

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTBCX-1812 (RWJ-270201): Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug DesignY. Sudhakar Babu, Pooran Chand, Shanta Bantia, Pravin Kotian, Ali Dehghani, Yahya El-Kattan, Tsu-Hsing Lin, Tracy L. Hutchison, Arthur J. Elliott, Cynthia D. Parker, Sandya L. Ananth, LaShun L. Horn, Graeme W. Laver, and John A. MontgomeryView Author Information BioCryst Pharmaceuticals, Inc., 2190 Parkway Lake Drive, Birmingham, Alabama 35244, and John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia Cite this: J. Med. Chem. 2000, 43, 19, 3482–3486Publication Date (Web):August 31, 2000Publication History Received22 June 2000Published online31 August 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/jm0002679https://doi.org/10.1021/jm0002679rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views4555Altmetric-Citations325LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Crystal structure,Hydrophobicity,Inhibitors,Molecular structure,Viruses Get e-Alerts