Portal de Periódicos da CAPES

Risk of relapse phenotype recurrence in multiple sclerosis

2014; SAGE Publishing; Volume: 20; Issue: 11 Linguagem: Inglês

10.1177/1352458514528762

1477-0970

Tomáš Kalinčík, Katherine Buzzard, Vilija Jokubaitis, Maria Trojano, Pierre Duquette, Guillermo Izquierdo, Marc Girard, Alessandra Lugaresi, Pierre Grammond, François Grand’Maison, Celia Oreja‐Guevara, Cavit Boz, Raymond Hupperts, Thor Petersen, Giorgio Giuliani, Gerardo Iuliano, Jeannette Lechner‐Scott, Michael Barnett, Roberto Bergamaschi, Vincent Van Pesch, Maria Pia Amato, Erik van Munster, Ricardo Fernández‐Bolaños, Freek Verheul, Marcela Fiol, Edgardo Cristiano, Mark Slee, Maria Edite Rio, Daniele Spitaleri, Raed Alroughani, Orla Gray, Maria Luisa Saladino, Sholmo Flechter, Joseph Herbert, José Antonio Cabrera-Gómez, Norbert Vella, Mark Paine, Cameron Shaw, Fraser Moore, Steve Vucic, Aldo Savino, Bhim Singhal, Tatjana Petkovska‐Boskova, Nevin John, Carmen Adella Sîrbu, Csilla Rózsa, Danny Liew, Helmut Butzkueven,

Systemic Sclerosis and Related Diseases

Objectives: The aim was to analyse risk of relapse phenotype recurrence in multiple sclerosis and to characterise the effect of demographic and clinical features on this phenotype. Methods: Information about relapses was collected using MSBase, an international observational registry. Associations between relapse phenotypes and history of similar relapses or patient characteristics were tested with multivariable logistic regression models. Tendency of relapse phenotypes to recur sequentially was assessed with principal component analysis. Results: Among 14,969 eligible patients (89,949 patient-years), 49,279 phenotypically characterised relapses were recorded. Visual and brainstem relapses occurred more frequently in early disease and in younger patients. Sensory relapses were more frequent in early or non-progressive disease. Pyramidal, sphincter and cerebellar relapses were more common in older patients and in progressive disease. Women presented more often with sensory or visual symptoms. Men were more prone to pyramidal, brainstem and cerebellar relapses. Importantly, relapse phenotype was predicted by the phenotypes of previous relapses. (OR = 1.8–5, p = 10 -14 ). Sensory, visual and brainstem relapses showed better recovery than other relapse phenotypes. Relapse severity increased and the ability to recover decreased with age or more advanced disease. Conclusion: Relapse phenotype was associated with demographic and clinical characteristics, with phenotypic recurrence significantly more common than expected by chance.