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InfecÇão crônica por Toxoplasma gondii induzindo hipertrofia de neurônios do plexo mientérico do cólon descendente de Rattus norvegicus

2009; Colégio Brasileiro de Parasitologia Veterinaria; Volume: 18; Issue: 02 Linguagem: Inglês

10.4322/rbpv.01802013

ISSN

1984-2961

Autores

Janine Soares, Neide Martins Moreira, Aristeu Vieira da Silva, Débora de Mello Gonçales Sant’Ana, Eduardo José de Almeida Araújo,

Tópico(s)

Herpesvirus Infections and Treatments

Resumo

The effects of the chronic infection due to Toxoplasma gondii tachyzoites on the myenteric neurons of the adult rat descending colon were assessed in this study.Ten male, 60-day-old, Wistar rats, divided into control and experimental group were orally inoculated with 10 5 tachyzoites from Toxoplasma gondii genotype I strain.After 30 days, the animals were anesthetized and submitted to laparotomy.The descending colon was removed, dissected, and the whole-mounts were staining by Giemsa, in order to observe neurons of the myenteric plexus, followed by quantitative and morphometric analysis.It was verified that the infection caused alterations neither with respect to the dimensions of the organ nor the neuronal population; however, there was a significant increase of the perikarion area and the cytoplasm.

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