The rabbit jugular vein is a contractile NK-1 receptor system
1990; Elsevier BV; Volume: 179; Issue: 3 Linguagem: Inglês
10.1016/0014-2999(90)90189-d
ISSN1879-0712
AutoresF. Nantel, N. Rouissi, Nour‐Eddine Rhaleb, Stéphane Dion, Guy Drapeau, D. Regoli,
Tópico(s)Complement system in diseases
ResumoRabbit isolated jugular veins respond to substance P and related neurokinins with cononcentration-dependent contractions which appears to be due to the activation of a single neurokinin receptor of the NK-1 type. This is demonstrated by the order of potency of neurokinins and some of their fragments as well as by the strong activity of NK-1-selective agonists and the weakness of NK-2 and NK-3-selective agonists. The present indicate that the rabbit jugular vein provides a sensitive, specific and selective NK-1 preparation which responds directly to neurokinins with contractions and therefore can be useful for characterization of NK-1 agonists and antagonists.
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