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N-Alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents

2008; Elsevier BV; Volume: 18; Issue: 6 Linguagem: Inglês

10.1016/j.bmcl.2008.01.104

1464-3405

Gui‐Bai Liang, Xiaoxia Qian, Dennis Feng, Michael H. Fisher, Tami Crumley, Sandra J. Darkin‐Rattray, Paula M. Dulski, Anne Gurnett, Penny Leavitt, Paul Liberator, Andrew S. Misura, Samantha Samaras, Tamas Tamas, Dennis M. Schmatz, Matthew J. Wyvratt, Tesfaye Biftu,

Veterinary medicine and infectious diseases

Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved.