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Application of mid-IR spectroscopy for the characterization of pharmaceutical systems

2010; Elsevier BV; Volume: 417; Issue: 1-2 Linguagem: Inglês

10.1016/j.ijpharm.2010.12.011

1873-3476

Bernard Van Eerdenbrugh, Lynne S. Taylor,

Drug Solubulity and Delivery Systems

In this article, the use of mid-IR in pharmaceutical settings is reviewed. An overview of mid-IR instrumentation and sampling techniques is provided. Subsequently, different pharmaceutical applications of the technique are described, including structure elucidation and identification, characterization of crystalline (polymorphs, hydrates, salts and co-crystals) and amorphous forms, as well as quantitative and remote sensing applications. Finally, an overview of current trends in FTIR-based imaging applications is provided, with special attention paid to currently emerging FTIR–AFM coupled techniques which have high spatial resolution.