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Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus

2007; Wiley; Volume: 79; Issue: 11 Linguagem: Inglês

10.1002/jmv.20942

1096-9071

Xiaoyang Mo, Wenli Ma, Yali Zhang, Zhao Haiquan, Yun Deng, Wuzhou Yuan, Yuequn Wang, Yongqin Li, Chuanbing Zhu, Mingyao Liu, Xiushan Wu,

Viral Infectious Diseases and Gene Expression in Insects

Abstract Changes in mRNA expression levels of ECV304 cells infected with the wild‐type rubella strain were analyzed using a microarray system representing 18,716 human genes. Four hundred eighty‐seven genes exhibited differential expression levels; 456 of these genes were up‐regulated while 31 genes were down‐regulated. We identified 53 biological processes that were significantly relevant to the RV‐infection. Among these biological processes, 52 were one‐gene processes and one was a process involving five genes: IFNA21 (interferon, alpha 21), interferon stimulated exonuclease gene 20 kDa (ISG20), zinc finger protein 175 (ZNF175), tripartite motif‐containing 22 (TRIM22), and MX2 [myxovirus (influenza virus) resistance 2 (mouse)]. Except for ZNF175, gene annotation indicated four of these genes encoded interferon or interferon‐induced genes. These results suggest that genes relevant to interferon‐regulated pathways may be involved in the pathogenesis of rubella. J. Med. Virol. 79:1783–1791, 2007. © 2007 Wiley‐Liss, Inc.