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Biomarkers in dementia: clinical utility and new directions

2014; BMJ; Volume: 85; Issue: 12 Linguagem: Inglês

10.1136/jnnp-2014-307662

1468-330X

Rebekah M. Ahmed, Ross W. Paterson, Jason D. Warren, Henrik Zetterberg, John T. O’Brien, Nick C. Fox, Glenda M. Halliday, Jonathan M. Schott,

Neurological Disease Mechanisms and Treatments

Imaging, cerebrospinal fluid (CSF) and blood-based biomarkers have the potential to improve the accuracy by which specific causes of dementia can be diagnosed in vivo, provide insights into the underlying pathophysiology, and may be used as inclusion criteria and outcome measures for clinical trials. While a number of imaging and CSF biomarkers are currently used for each of these purposes, this is an evolving field, with numerous potential biomarkers in varying stages of research and development. We review the currently available biomarkers for the three most common forms of neurodegenerative dementia, and give an overview of research techniques that may in due course make their way into the clinic.