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In Vitro Cytotoxicity of Some Natural and Semi-Synthetic Isocoumarins from Paepalanthus bromelioides

2002; De Gruyter; Volume: 57; Issue: 1-2 Linguagem: Inglês

10.1515/znc-2002-1-215

ISSN

1865-7125

Autores

Karina F. Devienne, Maria Stella G. Raddi, Eliana Aparecida Varanda, Wagner Vilegas,

Tópico(s)

Plant chemical constituents analysis

Resumo

Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy- 1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromelioides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.

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