Produção Nacional
Revisado por pares
Antioxidant activity and protective effect of Turnera ulmifolia Linn. var. elegans against carbon tetrachloride-induced oxidative damage in rats
2012; Elsevier BV; Volume: 50; Issue: 12 Linguagem: Inglês
10.1016/j.fct.2012.08.003
ISSN1873-6351
AutoresNaira Josele Neves de Brito, Jorge A. López, Maria Aparecida do Nascimento, José Benilson Martins Macedo, Gabriel Araújo da Silva, Cláudia Nunes Oliveira, Adriana Augusto de Rezende, José Brandão‐Neto, Aline Schwarz, Maria das Graças Almeida,
Tópico(s)Antioxidant Activity and Oxidative Stress
ResumoThe present study aimed to determine whether the leaves of Turnera ulmifolia Linn. var. elegans extract exert significant antioxidant activity. The antioxidant activity of its hydroethanolic extract (HEETU) was evaluated by assessing (a) its radical scavenging ability in vitro, and (b) its in vivo effect on lipid peroxidation and antioxidant enzyme activities. The in vitro antioxidant assay (DPPH) clearly supported HEETU free radical scavenging potential. Moreover, glutathione content and antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase and catalase) were significantly enhanced in CCl(4)-treated rats due to oral HEETU-treatment (500 mg/kgb.w.) over 7 and 21 days. In addition, an improvement was observed in lipid peroxidation and serum biochemical parameters (aspartate aminotransferase and alanine aminotransferase), indicating a protective effect against CCl(4)-induced liver injuries, confirmed by histopathological studies. The HEETU effect was comparable to the standard drug Legalon® (50 mg/kgb.w.) under the same experimental condition. Quantitative analysis of the HPLC extract revealed the presence of flavonoids, wich mediate the effects of antioxidant and oxidative stress. In conclusion, extract components exhibit antioxidant and hepatoprotective activities in vitro and in vivo.
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