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Choline stimulates the synthesis and accumulation of acetate in a cholinergic neuroblastoma clone

1977; Elsevier BV; Volume: 78; Issue: 1 Linguagem: Inglês

10.1016/0006-291x(77)91261-x

1090-2104

A.C. Kato, P. Lefresne, Yoheved Berwald‐Netter, J. C. Beaujouan, J. Głowiński, François Gros,

Mitochondrial Function and Pathology

Abstract The NS 20 mouse neuroblastoma clone was shown to synthesize acetylcholine from labelled glucose or acetate as precursor of the acetyl moiety of acetylcholine; in both cases, the synthesis was stimulated by the presence of exogenous choline. In addition, we report that acetate is accumulated in the NS 20 clone by a mechanism that is highly temperature-dependent and is stimulated by the presence of externally added choline.