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The Effectiveness of Rectal Administration of Insulin Suppository on Normal and Diabetic Subjects

1981; American Diabetes Association; Volume: 4; Issue: 4 Linguagem: Inglês

10.2337/diacare.4.4.454

1935-5548

Yoshimitsu Yamasaki, Motoaki Shichiri, Ryuzo Kawamori, Mikio Kikuchi, Toshihito Yagi, Sadao Arai, Ryohei Tohdo, Nobuyoshi Hakui, Nobuyoshi Oji, Hiroshi Abe,

Pharmacology and Obesity Treatment

The effectiveness of insulin administration by rectal suppository was examined in normal and non-insulin-dependent nonobese diabetic subjects. A 100-U insulin suppository (mean 1.8 U/kg) given to the diabetic subjects caused four times as great a fall in plasma glucose compared with the normal subjects given the same dose (mean 1.6 U/kg). The insulin response after suppository administration demonstrated a significantly positive correlation (r = 0.83, P less than 0.01) with the plasma glucose level before administration. Diabetic subjects given a 100-U insulin suppository (mean 1.7 U/kg) 15 min after meals three times daily showed a significant (P less than 0.05) improvement in postprandial hyperglycemia accompanied by a restoration of the normal circadian profile of plasma IRI and a reduction of urinary glucose from 26 +/- 5.9 to 2.0 +/- 1.0 g/day. No untoward reactions were observed. These data strongly imply a unique characteristic of the insulin suppository in spite of low bioavailability.