Pressure-volume relationships of tracheae in fetal newborn and adult rabbits
1981; Elsevier BV; Volume: 43; Issue: 3 Linguagem: Inglês
10.1016/0034-5687(81)90104-3
ISSN1872-7611
AutoresVinod K. Bhutani, S. David Rubenstein, Thomas H. Shaffer,
Tópico(s)Neonatal Respiratory Health Research
ResumoThe physical properties of the trachea in fetal, newborn, and adult rabbits change with age. Tracheal dimensions and pressure-volume relationships were determined in excised tracheae at a wide developmental age range (from early gestational age to infancy and adulthodd). At intraluminal pressures of 0 to 10 cm H2O, the tracheal specific compliance was 0.089 (cm H2O)−1 for a 21 day old fetus. By adulthood, the tracheal specific compliance decreased five fold to 0.017 (cm H2O)−1; a dramatic proportion of this reduction occurred during fetal life itself, followed by a steady, progressive decline to adult age. The volume of the tracheal segment, at intraluminal pressure fo 20 cm H2O, increased by 29% (adult), 41.5% (31 day fetus) and 113% (21 day fetus). Developmental alterations in the specific airway compliance suggest significant changes in anatomical dead space would occur as a function of maturation and airway transmural pressure.
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