Portal de Periódicos da CAPES

Long-term follow-up of patients with myocarditis and idiopathic dilated cardiomyopathy after immunomodulatory therapy

1994; Oxford University Press; Volume: 10; Issue: 1 Linguagem: Inglês

10.1111/j.1574-695x.1994.tb00012.x

1574-695X

Milutin Mirić, Aleksandra Mišković, Srđan Brkić, Jovan Vasiljević, Nenad Keserović, Milan Pešić,

Viral Infections and Immunology Research

The randomized clinical trial with interferon-α (IFN) or thymic hormones versus conventional therapy was conducted in patients with myocarditis and idiopathic dilated cardiomyopathy (IDC). We enrolled 180 patients to receive IFN (3–5 million units per day) for 3 months, thymomodulin (10 mg three times per week) for 2 months, or conventional therapy alone. Patients were followed-up for 7 years after the end of treatment. Left ventricular function, exercise tolerance and survival rate were significantly better at long-term follow-up in patients treated with IFN or thymomodulin, than in conventionally treated patients. These results implicate that immune modulating therapy might represent important contribution in the treatment of myocarditis and IDC.