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A model of T cell‐target interaction leading to lymphokine release

1987; Wiley; Volume: 65; Issue: 6 Linguagem: Inglês

10.1038/icb.1987.53

1440-1711

David McKinnon, Philip D. Hodgkin,

Immunotherapy and Immune Responses

Binding of antigenic cells by activated T lymphocytes can trigger the release of a number of soluble factors, including the lymphokine interleukin 3 (IL3). The cellular interactions between T cells and allogeneic cells which are involved in the triggering of lymphokine release from T cells are still poorly understood. We have examined the relationship between antigenic cell number, T cell number and IL3 release and have derived a steady state binding model which adequately accounts for the experimental data if it is assumed that triggering is an all or none phenomenon. We find that binding of at least two antigenic cells by an allo-reactive T cell is necessary to trigger lymphokine release.