The Million Women Study: a licence to kill other investigations?
2004; Elsevier BV; Volume: 113; Issue: 1 Linguagem: Inglês
10.1016/j.ejogrb.2003.12.001
ISSN1872-7654
AutoresMarius J. van der Mooren, Peter Kenemans,
Tópico(s)Cancer Risks and Factors
ResumoThe Million Women Study (MWS), published in the summer of 2003, has suggested unexpected high risks for invasive breast cancer in women using postmenopausal hormone therapy (PHT). Recent reports from randomised controlled trials (RCTs) have demonstrated that long-term combined PHT is associated with a small risk increase for invasive breast cancer, but not for death due to breast cancer. The observational design of the MWS has made this study subject to several biases, that can easily explain the discrepancy with the observations done in RCTs and several other large observational studies. It is concluded that the hormone fear that was caused by the MWS, and augmented by some professionals and the media, was unjustifiable.
Referência(s)