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Dengue virus infects mouse cultured neurons but not astrocytes

1994; Wiley; Volume: 42; Issue: 3 Linguagem: Inglês

10.1002/jmv.1890420304

1096-9071

José Luis Imbert Palafox, Patricia Guevara-Ramí­rez, José Ramos-Castañeda, Celso Ramos, Julio Sotelo,

Neuroinflammation and Neurodegeneration Mechanisms

Abstract Cultures of mouse brain cells containing a high proportion either neurons or astrocytes were inoculated with various strains of dengue virus. At analysis by double immunofluorescence, all strains of dengue virus studied were tropic for neurons. In no case were the astrocytes infected. Only ∼10% of all neurons were infected, suggesting that the virus may enter the cell through a membrane receptor present only in a subgroup of neurons. © 1994 Wiley‐Liss, Inc.