Potentiation of anti-cancer effect by intravenous administration of vesiculated α-tocopheryl hemisuccinate on mouse melanoma in vivo
2003; Elsevier BV; Volume: 192; Issue: 1 Linguagem: Inglês
10.1016/s0304-3835(02)00683-3
ISSN1872-7980
AutoresKentaro Kogure, Sachie Manabe, Susumu Hama, Akira Tokumura, Kenji Fukuzawa,
Tópico(s)Retinoids in leukemia and cellular processes
ResumoWe examined the effect of α-tocopheryl hemisuccinate (TS) on the growth of mouse melanoma cells B16-F1 inoculated on the back of hairless mice by two administration procedures of TS, i.p. administration of TS dissolved with dimethyl sulfoxide (TS i.p.) and i.v. administration of TS vesicles (TS-vesicle i.v.). TS i.p. significantly prevented the tumor growth of only half the mice in the group. However, TS-vesicle i.v. almost completely inhibited the tumor growth of all mice. Furthermore, the mean survival of the TS-vesicle i.v. group was 1.4-fold those of the control and TS i.p. groups.
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