Stimulation of sudomotor axon reflex mechanism by carbachol in healthy subjects and patients suffering from diabetic polyneuropathy
1995; Wiley; Volume: 91; Issue: 4 Linguagem: Inglês
10.1111/j.1600-0404.1995.tb06999.x
ISSN1600-0404
AutoresE. Lang, A. Spitzer, D. Claus, B. Neundörfer, Hermann O. Handwerker,
Tópico(s)Musculoskeletal pain and rehabilitation
ResumoActa Neurologica ScandinavicaVolume 91, Issue 4 p. 251-254 Stimulation of sudomotor axon reflex mechanism by carbachol in healthy subjects and patients suffering from diabetic polyneuropathy E. Lang, Corresponding Author E. Lang Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanyNeurologische Klinik der Universität Erlangen, Schwabachanlage 6, D-9–1054 Erlangen, GermanySearch for more papers by this authorA. Spitzer, A. Spitzer Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanySearch for more papers by this authorD. Claus, D. Claus Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanySearch for more papers by this authorB. Neundörfer, B. Neundörfer Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanySearch for more papers by this authorH. O. Handwerker, H. O. Handwerker Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanySearch for more papers by this author E. Lang, Corresponding Author E. Lang Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanyNeurologische Klinik der Universität Erlangen, Schwabachanlage 6, D-9–1054 Erlangen, GermanySearch for more papers by this authorA. Spitzer, A. Spitzer Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanySearch for more papers by this authorD. Claus, D. Claus Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanySearch for more papers by this authorB. Neundörfer, B. Neundörfer Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanySearch for more papers by this authorH. O. Handwerker, H. O. Handwerker Institut für Physiologie und Biokybernetik und Neurologische Klinik der Universität Erlangen-Nürnberg, GermanySearch for more papers by this author First published: April 1995 https://doi.org/10.1111/j.1600-0404.1995.tb06999.xCitations: 13AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Sudomotor axon reflex (SAR) mechanism was stimulated by percutaneous iontophoresis of carbachol in healthy subjects and patients suffering from diabetic polyneuropathy (PNP) of differing severity (stage I-III). SAR response was assessed by hygrometry and compared with histamine induced neurogenic vasodilatation (laser-Doppler flowmetry) and itching sensation (visual analogue scale), which may provide information on neuro-secretion and afferent function of nociceptive unmyelinated nerve fibers. Carbachol induced long lasting SAR response with maximal sweating rates 20–30 minutes after stimulus onset. In diabetic patients the carbachol induced SAR response and the histamine induced itching sensation were significantly reduced in stage III of PNP. In contrast, histamine induced vasodilatation was significantly impaired in all stages of PNP. It is concluded that prolonged SAR response following iontophoresis of carbachol can simplify evaluation of sudomotor function when compared to established tests using intradermal application of acetylcholine. 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