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Regional Intravenous Ketanserin and Guanethidine Therapy in Raynaud's Phenomenon

1991; SAGE Publishing; Volume: 42; Issue: 6 Linguagem: Inglês

10.1177/000331979104200607

1940-1574

Claudio A. Caputi, Giuliano De Carolis, Cristian Tomasetti,

Sympathectomy and Hyperhidrosis Treatments

The authors report the results of a study of 25 patients with Raynaud's phenomenon (primary, posttraumatic, and secondary to diffuse connective tissue deseases) treated with regional intravenous injections of guanethidine or ketanserin. These two drugs were chosen because of the different etiopathologic profiles of the conditions. All the patients showed a substantial clinical improvement with a remission of trophic lesions. Conditions secondary to connective tissue disorders did not demonstrate much improvement based on instrumental data alone, possibly because of the intrinsic limitations of the techniques used for evaluating peripheral blood flow. This specific type of pharmaceutical treatment appeared to be especially suitable for this disease owing to a combination of therapeutic efficacy and a substantial reduction in the total dosage for each patient.