Planarians as a model system for in vitro teratogenesis studies
1982; Wiley; Volume: 2; Issue: 3-4 Linguagem: Inglês
10.1002/1520-6866(1990)2
ISSN2472-1727
Autores Tópico(s)3D Printing in Biomedical Research
ResumoTeratogenesis, Carcinogenesis, and MutagenesisVolume 2, Issue 3-4 p. 277-291 Article Planarians as a model system for in vitro teratogenesis studies Jay Boyd Best, Corresponding Author Jay Boyd Best Department of Physiology and Biophysics, Colorado State University, Fort CollinsAddress reprint requests to Jay Boyd Best, Department of Physiology and Biophysics, Colorado State University, Fort Collins, CO 80523Search for more papers by this authorMichio Morita, Michio Morita Department of Physiology and Biophysics, Colorado State University, Fort CollinsSearch for more papers by this author Jay Boyd Best, Corresponding Author Jay Boyd Best Department of Physiology and Biophysics, Colorado State University, Fort CollinsAddress reprint requests to Jay Boyd Best, Department of Physiology and Biophysics, Colorado State University, Fort Collins, CO 80523Search for more papers by this authorMichio Morita, Michio Morita Department of Physiology and Biophysics, Colorado State University, Fort CollinsSearch for more papers by this author First published: 1982 https://doi.org/10.1002/1520-6866(1990)2:3/4 3.0.CO;2-8Citations: 61AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Free-living flatworms such as planarians are inexpensive to culture, maintain, and use for toxicologic testing in the laboratory. A considerable number of basic studies by ourselves and others indicate that, in simplified miniature, they possess many features of biochemical and physiologic organization similar to higher animals such as mammals. These include a well-developed brain with a varied behavioral repertoire including complex maneuvers of prey capture and learning, with a number of the same neurotransmitters used in mammalian brain. They are sensitive to a variety of the same toxicants. Undifferentiated totipotent stem cells, i.e., “neoblasts,” which are capable of mitosis and differentiation into any of the various specialized cell types, permit regeneration of complete planarians from fragments. They also provide new cells to replace those lost in the normal cellular turn-over of nonregenerating planarians. Both regeneration of surgical fragments and aberrant remodeling of whole planarians model important features of embyrogenesis and are potentially useful for assaying teratogens. Results are described from studies in which various representative teratogenic toxicants were tested in these two different planarian paradigms. The potential of planarian cephalic regeneration for behavioral teratogenesis investigations is also indicated. References 1 Best JB: The organization and evolution of sentient biological behavior systems. In AD Breck, W Yourgrau (eds): “ Biology, History and Natural Philosophy.” New York: Plenum Press, 1972, pp 37–78. 2 Best JB: Animal similarities and predictive toxicology. In A van der Merwe (ed): “ Old and New Problems in Philosophy, Physics, Cosmology and Theoretical Biology. 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