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PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

2015; American Association for the Advancement of Science; Volume: 347; Issue: 6218 Linguagem: Inglês

10.1126/science.1261971

1095-9203

Takashi Ochi, Andrew N. Blackford, Julia Coates, Satpal S. Jhujh, Shahid Mehmood, Naoka Tamura, Jon Travers, Qian Wu, Viji M. Draviam, Carol V. Robinson, Tom L. Blundell, Stephen P. Jackson,

Bacterial Genetics and Biotechnology

A factor for repairing broken DNA Unprogrammed DNA double-strand breaks are extremely dangerous for genomic stability. Nonhomologous end-joining (NHEJ) repair systems are present in all domains of life and help deal with these potentially lethal lesions. Ochi et al. have discovered a new factor involved in NHEJ by searching for proteins with structural similarities to known NHEJ proteins. Specifically, PAXX, a paralog of XRCC1 and XLF, interacts with a key repair pathway protein, Ku, and helps promote ligation of the broken DNA. Science , this issue p. 185