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Methoxyindoles and Photoreceptor Metabolism: Activation of Rod Shedding

1983; American Association for the Advancement of Science; Volume: 219; Issue: 4590 Linguagem: Inglês

10.1126/science.6828862

1095-9203

Joseph C. Besharse, Daiga A. Dunis,

Olfactory and Sensory Function Studies

Using an in vitro eye-cup preparation, we have evaluated a potential relationship between methoxyindole metabolism and photoreceptor disk shedding. Melatonin, 6-chloromelatonin, and 5-methoxytryptophol all activate rod disk shedding in culture. The effect is compound specific since serotonin and N-acetylserotonin are without effect, and it is similar to shedding in vivo because it is evoked by light and is quantitatively comparable to a normal intact animal response. The results suggest the involvement of 5-methoxyindoles in the control of rhythmic photoreceptor metabolism.