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DO THE NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES CYSTOSCOPIC CRITERIA ASSOCIATE WITH OTHER CLINICAL AND OBJECTIVE FEATURES OF INTERSTITIAL CYSTITIS?

2005; Lippincott Williams & Wilkins; Volume: 173; Issue: 1 Linguagem: Inglês

10.1097/01.ju.0000146466.71311.ab

1527-3792

Deborah Erickson, John E. Tomaszewski, Allen R. Kunselman, Christina M. Bentley, Kenneth M. Peters, Eric S. Rovner, Laurence M. Demers, Marcia A. Wheeler, Susan Keay,

Urinary Tract Infections Management

No AccessJournal of UrologyAdult Urology: Infection/Inflammation1 Jan 2005DO THE NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES CYSTOSCOPIC CRITERIA ASSOCIATE WITH OTHER CLINICAL AND OBJECTIVE FEATURES OF INTERSTITIAL CYSTITIS? DEBORAH R. ERICKSON, JOHN E. TOMASZEWSKI, ALLEN R. KUNSELMAN, CHRISTINA M. BENTLEY, KENNETH M. PETERS, ERIC S. ROVNER, LAURENCE M. DEMERS, MARCIA A. WHEELER, and SUSAN K. KEAY DEBORAH R. ERICKSONDEBORAH R. ERICKSON More articles by this author , JOHN E. TOMASZEWSKIJOHN E. TOMASZEWSKI More articles by this author , ALLEN R. KUNSELMANALLEN R. KUNSELMAN More articles by this author , CHRISTINA M. BENTLEYCHRISTINA M. BENTLEY More articles by this author , KENNETH M. PETERSKENNETH M. PETERS More articles by this author , ERIC S. ROVNERERIC S. ROVNER More articles by this author , LAURENCE M. DEMERSLAURENCE M. DEMERS More articles by this author , MARCIA A. WHEELERMARCIA A. WHEELER More articles by this author , and SUSAN K. KEAYSUSAN K. KEAY More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000146466.71311.abAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We compared urine markers, bladder biopsy findings and clinical features of patients with symptoms of interstitial cystitis (IC) who did or did not meet the cystoscopic criteria defined by the National Institute of Diabetes and Digestive and Kidney Diseases. Materials and Methods: Urine markers and symptom questionnaires were measured before and 1 month after bladder distention for IC. Bladder biopsies were taken at the time of distention. At distention patients were defined as meeting or not meeting the National Institute of Diabetes and Digestive and Kidney Diseases established cystoscopic criteria for IC. The 2 patient groups were compared. Results: Urine marker levels were similar for the 2 groups, including antiproliferative factor, epidermal growth factor, heparin binding epidermal growth factor-like growth factor, cyclic guanosine monophosphate, interleukins 6 and 8, and methylhistamine. Bladder biopsy features were similar for the 2 groups. Bladder capacity with the patients under anesthesia was higher in those who did not meet the criteria (median 750 vs 1,000 ml, p = 0.005). Median age at symptom onset was 26 years in both groups. On the University of Wisconsin symptom scale patients who met the criteria had higher scores for daytime frequency (p = 0.002) and nocturia (p = 0.01). Symptom characteristics and symptom response after bladder distention were similar for the 2 groups. Conclusions: Patients who met the cystoscopic criteria had worse daytime frequency and nocturia, and lower bladder capacity under anesthesia. However, the 2 groups had similar urine markers and bladder biopsy findings. 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Volume 173Issue 1January 2005Page: 93-97 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.KeywordsphysiopathologypathologyurinediagnosiscystitisinterstitialMetricsAuthor Information DEBORAH R. ERICKSON More articles by this author JOHN E. TOMASZEWSKI More articles by this author ALLEN R. KUNSELMAN More articles by this author CHRISTINA M. BENTLEY More articles by this author KENNETH M. PETERS More articles by this author ERIC S. ROVNER More articles by this author LAURENCE M. DEMERS More articles by this author MARCIA A. WHEELER More articles by this author SUSAN K. KEAY More articles by this author Expand All Advertisement PDF downloadLoading ...