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Niemann-Pick Disease Experimental Model: Sphingomyelinase Reduction Induced by AY-9944

1977; American Association for the Advancement of Science; Volume: 196; Issue: 4287 Linguagem: Inglês

10.1126/science.66749

1095-9203

Norio Sakuragawa, M Sakuragawa, Toichiro Kuwabara, Peter G. Pentchev, John A. Barranger, Roscoe O. Brady,

Adenosine and Purinergic Signaling

Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis.