Immune thrombocytopenia in severe hemophilia A treated with high‐dose intravenous immunoglobulin
1986; Wiley; Volume: 26; Issue: 1 Linguagem: Inglês
10.1046/j.1537-2995.1986.26186124036.x
ISSN1537-2995
AutoresSimon Panzer, U. Zeitelhuber, Viola Hach, H.‐H. Brackmann, H. Niessner, C. Mueller‐Eckhardt,
Tópico(s)Chronic Myeloid Leukemia Treatments
ResumoFive patients with severe hemophilia A receiving long‐term treatment with commercial factor VIII concentrates developed severe immune thrombocytopenia (ITP, platelet counts <20 × 10 9 /l). Concomitantly, they presented with a marked elevation of serum IgG concentrations (mean, 2364 mg/dl; range, 1712–2954 mg/dl). In four patients, the T helper to suppressor cell ratio was below 1. Treatment with high‐dose intravenous immunoglobulin (IgG, 7s) at doses of 0.2g (n = 2) or 0.4 g (n = 3) per kg of body weight on 5 consecutive days was effective immediately. The bleeding tendency ceased and platelet counts rose transiently. In three cases, treatment was repeatedly effective and patients underwent uneventful splenectomies. Thus, high‐dose IgG therapy may serve as a life‐saving agent in patients with severe hemophilia complicated by ITP.
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