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Urinary Stress Incontinence Due to Intrinsic Sphincteric Deficiency: Experience With Fat and Collagen Periurethral Injections

1997; Lippincott Williams & Wilkins; Volume: 157; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(01)64951-6

1527-3792

François Haab, Philippe E. Zimmern, Gary E. Leach,

Urological Disorders and Treatments

No AccessJournal of UrologyClinical Urology: Original Article1 Apr 1997Urinary Stress Incontinence Due to Intrinsic Sphincteric Deficiency: Experience With Fat and Collagen Periurethral Injections Francois Haab, Philippe E. Zimmern, and Gary E. Leach Francois HaabFrancois Haab More articles by this author , Philippe E. ZimmernPhilippe E. Zimmern More articles by this author , and Gary E. LeachGary E. Leach More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64951-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We prospectively compared the efficacy of 2 bulking agents to treat incontinence related to intrinsic sphincter deficiency. Materials and Methods: A total of 67 women underwent periurethral injection for intrinsic sphincter deficiency at the same institution performed by 1 surgeon. Patients were divided into 45 who received fat (group 1) and 22 who received collagen (group 2) injections. Both groups were comparable for age, parity, number of previously failed procedures and number of pads used daily. Preoperative urodynamic evaluation revealed a low Valsalva leak point pressure in both groups (mean plus or minus standard deviation 23.82 +/− 12.41 versus 29.35 +/− 11.32, not significant). Patients rated the subjective degree of postoperative improvement as 0 to 100%. Results: At a mean followup of 7 months after the last injection only 13% of the fat group and 24% of the collagen group were cured. The mean percentage of subjective improvement was significantly greater in the collagen than in the fat group (70.9 +/− 28 versus 31.2 +/− 41.7%, respectively, p <0.001). The failure rate was significantly greater in the fat group compared to the collagen group (p <0.001). Conclusions: Based on results of a prospective comparison of fat and collagen injection, collagen is more effective than fat for treatment of intrinsic sphincter deficiency. References 1 : Pathophysiology of lower urinary tract dysfunction. Urol. Clin. N. Amer.1985; 12: 215. Google Scholar 2 : Stress incontinence: classification and surgical approach. J. Urol.1988; 139: 727. Link, Google Scholar 3 : Periurethral injection therapy for the treatment of urinary incontinence. Brit. J. Urol.1995; 76: 151. Google Scholar 4 : Periurethral Teflon injection for urinary incontinence. J. Urol.1974; 111: 180. Link, Google Scholar 5 : Disappointing effect of endoscopic Teflon injection for female stress incontinence. Eur. Urol.1991; 20: 197. Google Scholar 6 : Complications of Teflon injection for stress urinary incontinence. Neurourol. Urodynam.1993; 12: 131. Google Scholar 7 : Migration and granulomatous reaction after periurethral injection of polytef (Teflon). J.A.M.A.1984; 251: 3277. 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Google Scholar From the Departments of Urology, Kaiser Permanente Medical Center, Los Angeles, California, Hopital Tenon, Paris, France, and University of Texas, Southwestern Medical Center, Dallas, Texas© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byLecoeur C, Swieb S, Zini L, Rivière C, Combrisson H, Ghérardi R, Abbou C and Yiou R (2007) Intraurethral Transfer of Satellite Cells by Myofiber Implants Results in the Formation of Innervated Myotubes Exerting Tonic ContractionsJournal of Urology, VOL. 178, NO. 1, (332-337), Online publication date: 1-Jul-2007.PANNEK J, BRANDS F and SENGE T (2018) PARTICLE MIGRATION AFTER TRANSURETHRAL INJECTION OF CARBON COATED BEADS FOR STRESS URINARY INCONTINENCEJournal of Urology, VOL. 166, NO. 4, (1350-1353), Online publication date: 1-Oct-2001.LEE P, KUNG R and DRUTZ H (2018) PERIURETHRAL AUTOLOGOUS FAT INJECTION AS TREATMENT FOR FEMALE STRESS URINARY INCONTINENCE: A RANDOMIZED DOUBLE-BLIND CONTROLLED TRIALJournal of Urology, VOL. 165, NO. 1, (153-158), Online publication date: 1-Jan-2001.CULLIGAN P, RACKLEY R, KODURI S, THOMSON R, SCHWABE L and SAND P (2018) IS IT SAFE TO REUSE A SYRINGE OF GLUTARALDEHYDE CROSS-LINKED COLLAGEN? A MICROBIOLOGICAL STUDYJournal of Urology, VOL. 164, NO. 4, (1275-1276), Online publication date: 1-Oct-2000.TSCHOPP P, WESLEY-JAMES T, SPEKKENS A and LOHFELD L (2018) COLLAGEN INJECTIONS FOR URINARY STRESS INCONTINENCE IN A SMALL URBAN UROLOGY PRACTICE: TIME TO FAILURE ANALYSIS OF 99 CASESJournal of Urology, VOL. 162, NO. 3 Part 1, (779-783), Online publication date: 1-Sep-1999. Volume 157Issue 4April 1997Page: 1283-1286 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Francois Haab More articles by this author Philippe E. Zimmern More articles by this author Gary E. Leach More articles by this author Expand All Advertisement PDF downloadLoading ...