Morphologic and pathologic aspect of intercalated disc of the heart
1969; Elsevier BV; Volume: 78; Issue: 3 Linguagem: Inglês
10.1016/0002-8703(69)90043-x
ISSN1097-6744
AutoresG.E. Burch, Rajindar S. Sohal,
Tópico(s)Ion channel regulation and function
ResumoMyocardial tissue is divided into discreet cellular units by the intercalated disc at the intercellular boundary. The intercalated disc is structurally differentiated into four regions. The tight junction or nexal region of the intercalated disc has been considered the region of low electrical resistance, thus acting as a pathway for the electrotonic coupling between myocytes. Under various pathologic and physiologic conditions, there is a variable degree of separation of the intercalated disc. The role of the intercalated disc in the propagation of the excitation impulse in normal and diseased states is discussed.
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