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Idiosyncratic Reaction to 25-Hydroxylated Vitamin D_3

1974; American College of Physicians; Volume: 80; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-80-3-416

1539-3704

Charles G. Gegick, T. S. Danowski, Hector F. De Luca, Michael F. Holick,

Blood disorders and treatments

Letters1 March 1974Idiosyncratic Reaction to 25-Hydroxylated Vitamin D3CHARLES G. GEGICK, M.D., T.S. DANOWSKI, M.D., F.A.C.P., HECTOR F. DE LUCA, M.D., MICHAEL F. HOLICK, M.D.CHARLES G. GEGICK, M.D.Search for more papers by this author, T.S. DANOWSKI, M.D., F.A.C.P.Search for more papers by this author, HECTOR F. DE LUCA, M.D.Search for more papers by this author, MICHAEL F. HOLICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-3-416 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have administered hydroxylated derivatives of cholecalciferol or vitamin D3 (25(OH)-cholecalciferol, 1,25 dihydroxycholecalciferol, and 1-alpha hydroxycholecalciferol) to a 47-year-old woman with postthyroidectomy hypothyroidism, controlled with desiccated thyroid, and hypoparathyroidism and pruritus resistant to large dosages of calcium lactate and vitamin D2 (Table 1).In the dosages tested, each of the three hydroxylated derivatives was equally effective in controlling the severe pruritis, even though increases in serum calcium levels, if any, were slight, and the serum inorganic phosphorus remained high. Headache, nausea, vomiting, diarrhea, and fever occurred, however, in the last 4 weeks of the initial 5-month course...References1. FRASERKOOHKIND DSH: Pathogenesis of hereditary vitamin-D-dependent rickets. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1-alpha, 25-dihydroxyvitamin D. N Engl J Med 289:817-882, 1973 CrossrefMedlineGoogle Scholar2. CHALMERSDAVIEHUNTER TMJ: 1-alpha-hydroxycholecalciferol as a substitute for the kidney hormone 1, 25-dihydroxycholecalciferol in chronic renal failure. Lancet 2:696-699, 1973 CrossrefMedlineGoogle Scholar3. DENTGARRETTS CM: Skin changes in hypocalcemia. Lancet 1:142-146, 1960 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByVitamin D analoguesVitamin D analoguesKnochenumbau und Calciumphosphat-StoffwechselThe therapeutic approach to hypoparathyroidism 1 March 1974Volume 80, Issue 3Page: 416-417KeywordsCalciumHeadachesHypoparathyroidismHypothyroidismLactatesNauseaPhosphorusPruritusThyroidVomiting Issue Published: 1 March 1974 PDF DownloadLoading ...