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Synthetic studies towards complex diterpenoids. Part 19. Total synthesis of (±)-deoxofaveline, (±)-faveline methyl ether and (±)-faveline

1994; Issue: 3 Linguagem: Inglês

10.1039/p19940000327

2050-8255

Ajit Ghosh, Chhanda Mukhopadhyay, U. R. GHATAK,

Plant biochemistry and biosynthesis

Simple and efficient syntheses have been developed for the cytotoxic dinorditerpenoids, (±)-deoxofaveline 1, (±)-faveline methyl ether 2 and (±)-faveline 3, having a hexahydrodibenzo[a,d]cycloheptene ring system, through the enolizable tricyclic ketone mixture 12 and 13, prepared from the easily accessible 2-arylethyl-3,3-dimethylcyclohexanone 7.