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Improved synthesis of trifluoromethyl sulfones used as intermediates for the preparation of di- or tri-substituted olefins

1994; Elsevier BV; Volume: 66; Issue: 3 Linguagem: Inglês

10.1016/0022-1139(93)02909-x

1873-3328

Fabrice Eugene, Bernard R. Langlois, E. LAURENT,

Chemical Reaction Mechanisms

Primary and secondary trifluoromethyl sulfones (triflones) are efficiently obtained from easily available sodium trifluoromethanesulfinate (triflinate) and alkyl bromides in N,N-dimethylacetamide. This technique is more powerful than the potassium triflinate/acetonitrile system. Ethyl aconitate can be also produced in one step from ethyl bromoacetate and diisopropylethylamine, sodium triflinate being a catalyst.