Analytical and Preparative Instrumentation
2012; Elsevier BV; Volume: 17; Issue: 6 Linguagem: Inglês
10.1177/1087057112447182
ISSN2472-5560
Autores ResumoBAC BV and Life Technologies now offer a range of POROS CaptureSelect affinity columns. By combining BAC’s CaptureSelect affinity ligand technology with Life Technologies’ POROS resin, the companies now offer a platform for high-speed, high-performance product-specific process monitoring for a broad range of biomolecules. The POROS CaptureSelect line of analytical columns offers precise quantitation of important classes of biomolecules in minutes. The initial product line includes POROS CaptureSelect LC-kappa and POROS CaptureSelect LC-lambda for the analysis of human antibodies and antibody fragments containing either a kappa or a lambda light chain; POROS CaptureSelect IgG-Fc for the detection of any human IgG subclass (even IgG3) in the presence of IgG from other sources (e.g., bovine); POROS CaptureSelect IgM for the analysis of human, mouse, and rat IgM; and POROS CaptureSelect HAS for the analysis of HSA-fusion proteins (specific for human serum albumin in the presence of albumin from other species). The affinity resins are offered in four different column sizes (0.1- to 7.9-mL column volumes). More: www.lifetechnologies.com/poros/captureselect New Optima X Series preparative ultracentrifuges now offer large touchscreen displays with a selection of nine languages. The screen is big enough to be visible from across a lab and is easy to operate, even with gloved hands. Clean, intuitive design and on-screen help make it easy even for new users to quickly get acclimated and working. Real-time graphing plots speed and temperature over time as a run progresses. Enhanced remote control capabilities allow the ultracentrifuges to be monitored from a personal computer or a smartphone. Should on-board diagnostics sense a problem or out-of-parameter condition, an e-mail can alert the user. High-level security and tracking features enable users in regulated environments to track run history and to keep run logs, and new electronic signature capabilities can be used to approve a run. Regenerative braking captures the energy generated in slowing the rotor and applies it back to the lab’s local circuit, reducing overall energy costs. When powered on but not running, the unit requires the same energy as a 60-watt incandescent bulb. Optima X Series ultracentrifuges reach a maximum speed of 100 000 rpm and generate forces up to 802 000 g with noise output of less than 51 dBa. Optima X Series instruments are available in two models: the XE, which delivers all of the basic features required to quickly set up and complete a run, and the XPN, which includes all features of the XE plus networking capability, on-board simulation tools, and a variety of customizable security and tracking features. The XE is available in 90 000– and 100 000–rpm configurations, whereas the XPN is offered in 80 000–, 90 000–, and 100 000–rpm configurations. More: www.beckmancoulter.com A new filter-based technique, using an Exeter Analytical Model 440 CHN Elemental Analyzer, provides rapid and routine analysis of marine sediment. Results are expressed in micrograms of carbon and nitrogen detected, simplifying the calculation process. Analytical sensitivity is less than 1 µg. As the Model 440 provides complete control over combustion parameters, it is able to reproducibly achieve 100% combustion with the widest range of sediment samples. Proprietary nitrogen analysis software uniquely enables accurate measurement of low nitrogen levels (in the 0.1%–0.2% range) with a high degree of accuracy. The Model 440 is a static combustion system, with a unique horizontal furnace design, which enables easy removal of filter and sample ash between each sediment analysis. Consequently, one combustion tube will analyze in excess of 1000 sediment samples without the need for removal and cleaning. In addition, the Model 440 provides the capacity to process filters up to 47 mm in diameter in one analytical cycle. More: sales@eai1.com According to Exeter Analytical, its new Linear Regression Plus software algorithm improves data quality and reduces the time taken to accurately determine the nitrogen content of combustible samples. The software capability is available as standard on all new Exeter Analytical Model 440 Elemental Analyzers or as a free-of-charge upgrade to existing users of Model 440 Windows-based software. More: www:exeteranalytical.co.uk Fluid Metering Inc.’s (FMI’s) miniature “H” Series Pump Heads are now available with an isolation gland to provide a fluid barrier between the pumped process fluid and atmosphere. These pumps are considered ideal for maintenance-free dispensing of saline-based reagents, buffers and wash fluids, slurries, abrasive fluids, fluids with particulates, inks, pigments, anaerobic fluids, dialysate used for hemodialysis, and more. Isolation gland pumps have a pair of extra ports that connect to a fluid source (either liquid or gas). The fluid flowing through the gland ports provides a barrier that isolates the pumped process fluid from the seal area and atmosphere. The isolation gland is easily connected to the “barrier” liquid or gas source via barbed fittings. FMI’s “H” Series Pump Heads can be configured with all of FMI’s drive options, including AC, DC, hazardous duty, pneumatic and stepper, and programmable dispensing systems. More: www.fmipump.com/oem.html This new series of dual-beam, UV-visible spectrophotometers includes Ultrospec 7000/7000PC for day-to-day laboratory activities, Ultrospec 8000/8000PC, and the top-of-the-range 9000/9000PC system for demanding assays. Each version is available as either a stand-alone or PC-controlled system. The Ultrospec range benefits from a dual-beam instrument with a variety of bandwidths. The Ultrospec 7000/ 7000PC offers a 2-nm bandwidth, the Ultrospec 8000/8000PC offers a 1-nm bandwidth, and the Ultrospec 9000/9000PC offers variable bandwidth optics for difficult samples. Other features include a color touchscreen for the stand-alone product, USB data and PC connectivity, European Pharmacopoeia research compatibility (8000/9000 models), Datrys Standard (option to upgrade to Datrys Life Science or Datrys CFR), and Equation Editor software, enabling custom calculations on measured data. Plus, an extended range of accessories is available, including thermostatting and Bluetooth and Datrys software options. More: www.gelifesciences.com/ultrospec The SecurityGuard ULTRA system extends the lifetime of columns packed with sub-2 micron fully porous or core-shell particles by protecting against the damaging effects of chemical contaminants and microparticulates introduced by the sample, mobile phase, or system. These contaminants can also affect method sensitivity, quantitation, and peak identification. The new SecurityGuard ULTRA product is considered ideal for any manufacturer’s ultra-high-performance liquid chromatography (UHPLC), sub-2 micron, or core-shell widepore (≥200 Å) columns, including the Phenomenex Aeris widepore XB-C18, XB-C8, and C4 products. Pressure rated up to 20 000 psi (1378 bar), these widepore guard cartridges have no significant impact on chromatography, backpressure, or dead volume. A Phenomenex Web page at http://www.phenomenex.com/GuardIt offers application and technical notes, helpful videos, and an interactive application through which users can enter their UHPLC, sub-2 micron, or core-shell column information to find the right SecurityGuard ULTRA column protection system. More: www.phenomenex.com Uniqsis and WaveCraft entered into a collaborative agreement to develop and market a new range of microwave-based flow chemistry systems to improve efficiency when scaling up compound synthesis during drug development. By integrating liquid handling technology from Uniqsis with microwave applicator technology and reactors from WaveCraft, the two companies will deliver flow chemistry systems that not only speed up synthetic processes and facilitate scale-up but also offer a safe solution that uses less energy than conventional approaches. WaveCraft’s technology uses a novel applicator and a microwave generator based on mobile phone technology to apply microwave energy and accelerate chemical reactions. This makes it possible to effectively and safely combine flow chemistry with microwave heating. Users will be able to continuously change power and frequency, enabling optimization during synthesis. They will be able to scale up with no need to reoptimize conditions. More: www.uniqsis.com or www.wavecraft.se According to World Precision Instruments, this novel cell biology research tool is designed for the field of mechanotransduction and allows users to study the influence of mechanical force, stress, or strain on cells and how these cells react to stimuli. Working at a rate of over 1000 measurements per second, the Cell Tester employs optics, nanopositioning, and force sensor technology to deliver sensitive, robust, and reproducible force measurements. This facilitates the quantification of the very small forces that individual cells can generate—on the order of tens to hundreds of nanograms. At the same time, the instrument uses miniature piezo crystal–based motors to push or pull cells, thereby changing their length or imposing stress. For most cell types, fine alignment is achieved using a rotating stage and remote-controlled micro-tweezers that approach and grab onto the individual cell. However, for a very small subset of cells that produce high forces in relation to their size (e.g., heart muscle cells), this “grabbing” technique is not suitable; instead, these cells are held in place by polymerizing mixtures of very sticky natural biological compounds that cells use to adhere to one another combined with glass rods held by the micro-grabbers. One such “glue” is Myotak, specially designed to securely hold muscle cells and allow measurement without crushing of the cell. More: www.wpiinc.comAbout the JBS Product Focus ColumnE-mail news releases for consideration to nhallock@slas.org. MSWord documents and 300+ dpi image files are preferred. Deadlines are at least two months prior to publication. JBS editors reserve the right to select the products they deem most appropriate for the section and may revise copy as necessary. Product descriptions are based on information provided by the manufacturer. Inclusion in this section in no way implies endorsement by the Journal of Biomolecular Screening or the Society for Laboratory Automation and Screening. E-mail news releases for consideration to nhallock@slas.org. MSWord documents and 300+ dpi image files are preferred. Deadlines are at least two months prior to publication. JBS editors reserve the right to select the products they deem most appropriate for the section and may revise copy as necessary. Product descriptions are based on information provided by the manufacturer. Inclusion in this section in no way implies endorsement by the Journal of Biomolecular Screening or the Society for Laboratory Automation and Screening.
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