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The Effect of Treatment in Patients with Chronic Myelogenous Leukemia

1963; American College of Physicians; Volume: 59; Issue: 5_Part_1 Linguagem: Inglês

10.7326/0003-4819-59-5-622

1539-3704

Paul P. Carbone,

Acute Myeloid Leukemia Research

Article1 November 1963The Effect of Treatment in Patients with Chronic Myelogenous LeukemiaHematologic and Cytogenetic StudiesPAUL P. CARBONE, M.D., J. H. TJIO, M.D., JACQUELINE WHANG, M.D., JEROME B. BLOCK, M.D., WILLIAM B. KREMER, M.D., EMIL FREI III, M.D.PAUL P. CARBONE, M.D.Search for more papers by this author, J. H. TJIO, M.D.Search for more papers by this author, JACQUELINE WHANG, M.D.Search for more papers by this author, JEROME B. BLOCK, M.D.Search for more papers by this author, WILLIAM B. KREMER, M.D.Search for more papers by this author, EMIL FREI III, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-5-622 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChemotherapy or X irradiation produces improvement in the clinical and hematologic abnormalities in the majority of patients with chronic myelogenous leukemia (CML) (1-5). Return of the leukocyte alkaline phosphatase (LAP) and bone marrow morphology toward normal has been described but is less frequent (6-11). Recently, Tough and co-workers (12) have reported that the chromosome abnormality (Ph1) which is present in the majority of patients with CML disappears from the peripheral blood but not from the marrow after splenic X irradiation. The present study was designed to determine the relative frequency and magnitude of response of clinical, hematologic, and cytogenetic abnormalities...References1. RUNDLESGRIZZLEBELLCORLEYFROMMEYERGREENBERGHUGULEYJAMESJONESLARSENLOEBLEONEPALMERRISERWILSON RWJWNCCWBBGCMGWRWEVLAJGWHSJ: Comparison of chlorambucil and myleran in chronic lymphocytic and granulocytic leukemia. Amer. J. Med. 27: 424, 1959. CrossrefGoogle Scholar2. HAUTABBOTTWINTROBECARTWRIGHT AWSMMGE: Busulfan in the treatment of chronic myelocytic leukemia. The effect of long term intermittent therapy. Blood 17: 1, 1961. CrossrefMedlineGoogle Scholar3. 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Elsevier Publishing Company, Amsterdam, 1958, p. 84. Google Scholar32. ELVESBUTTOOISRAELSWILKINSON MWASMCJF: Chromosome changes caused by 6-azauridine during treatment of acute myeloblastic leukaemia. Brit. Med. J. 1: 156, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland.Requests for reprints should be addressed to Paul P. Carbone, M.D., Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDie chronische myeloische LeukämieChromosomal Changes in Human Tumors and LeukemiasThe Spectrum of Myeloproliferative DisordersAnomalies of the Small Acrocentric (chromosomes in Human Tumour Cells*Granulopoiesis in Chronic Granulocytic LeukaemiaUnfavorable Signs in Patients with Chronic Myelocytic LeukemiaATHANASIOS THEOLOGIDES, M.D., Ph.D., F.A.C.P.Das Philadelphia ChromosomThe myeloproliferative disordersBusulfanSPECIFICITY OF THE Ph1 CHROMOSOMEPh1 PREVALENCE, PERIPHERAL BLOOD PICTURE AND CYTOSTATIC THERAPYCYTOGENETIC STUDIES IN CHRONIC GRANULOCYTIC LEUKAEMIAChromosomenuntersuchungen bei chronisch-myeloischer LeukämieProgress in treatment for the leukemias and lymphomasComparison of Philadelphia Chromosome-Positive and -Negative Patients with Chronic Myelocytic LeukemiaSTEPHEN KRAUSS, M.D., JOSEPH E. SOKAL, M.D., AVERY A. SANDBERG, M.D.TWO CASES OF CHRONIC MYELOID LEUKAEMIA WITH PRESUMABLY IDENTICAL 47-CHROMOSOME CELL-LINES IN THE BLOODSeveral Cell-Lines with Abnormal Karyotypes in a Patient with Chronic Myelogenous Leukaemia 1 November 1963Volume 59, Issue 5_Part_1Page: 622-628KeywordsBone marrowCancer treatmentChemotherapyChromosomesChronic myelocytic leukemiaChronic myelogenous leukemiaCytogeneticsPatientsPhosphatasesX chromosomes Issue Published: 1 November 1963 PDF DownloadLoading ...