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Inbreeding effects on prereproductive mortality: a case-control study in Saguenay-Lac-Saint-Jean (Québec, Canada) based on a population registry 1838–1971

1993; Informa; Volume: 20; Issue: 6 Linguagem: Inglês

10.1080/03014469300002942

1464-5033

Michael B. Edmond, Marc De Braekeleer,

Iron Metabolism and Disorders

SummaryEffects of inbreeding on the prereproductive mortality, excluding spontaneous abortions, were investigated among offspring of 251 marriages between first-degree cousins (2:2) and 358 marriages between first-degree cousins once removed (2:3) from Saguenay-Lac-Saint-Jean. A control group matched on the demographic and socioeconomic characteristics of the consanguineous marriages was created. The mortality rates were calculated from a computerized population registry. The stillbirth rate was not significantly higher in the 2:2 and 2:3 groups compared with their respective control groups (p>0·05). Mortality during the first year was significantly higher in both consanguineous groups (p 0·05). In Saguenay-Lac-Saint-Jean, less than 1% of the prereproductive mortality, excluding spontaneous abortions, can be attributed to consanguineous marriages. This study is in agreement with previous reports showing that inbreeding had a minor impact in prereproductive mortality.