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High-sensitivity C-reactive Protein Level is an Independent Predictor of Poor Prognosis in Cirrhotic Patients With Spontaneous Bacterial Peritonitis

2013; Lippincott Williams & Wilkins; Volume: 48; Issue: 5 Linguagem: Inglês

10.1097/mcg.0b013e3182a6cdef

1539-2031

Yuri Cho, So Youn Park, Jeong‐Hoon Lee, Dong Hyeon Lee, Minjong Lee, Jeong‐Ju Yoo, Won‐Mook Choi, Young Youn Cho, Yun Bin Lee, Jae Woong Yoon, Jung Hee Kwon, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo‐Suk Lee,

Amoebic Infections and Treatments

The production of high-sensitivity C-reactive protein (hs-CRP) may be affected by hepatic function, and the clinical importance of hs-CRP in patients with liver cirrhosis is still not clear. The aim of this study was to evaluate the clinical implications of hs-CRP in cirrhotic patients with spontaneous bacterial peritonitis (SBP).We retrospectively investigated 336 consecutive patients treated for SBP from 2007 to 2012. The relationship between serum hs-CRP and the result of the treatment was assessed.A response to antibiotics was observed in 182 patients (54.2%), and 126 patients (37.5%) died of SBP. The initial hs-CRP (odds ratio=1.061, P=0.016), coexistent hepatocellular carcinoma, and Child-Pugh (CP) score were independent prognostic factors for high in-hospital mortality. Serum hs-CRP level was also an independent predictor of lower antibiotic response rate (odds ratio=0.916, P<0.001). However, hs-CRP was negatively correlated with the CP score (r=-0.199, P<0.001) and Model for End-Stage Liver Disease score (r=-0.182, P=0.001).This study found that serum hs-CRP level is related to a lower response rate to antibiotics, a higher mortality rate in patients with SBP. The hs-CRP level was negatively correlated with the CP and Model for End-Stage Liver Disease scores, which suggests that the prognostic function of hs-CRP was not a surrogate for hepatic dysfunction.