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Effect of high-dose steroid therapy on T-cell subpopulations A longitudinal study in MS patients

2009; Wiley; Volume: 89; Issue: 2 Linguagem: Inglês

10.1111/j.1600-0404.1994.tb01642.x

1600-0404

Paolo Gallo, M. Chiusole, M. Sanzari, S. Sivieri, Maria Grazia Piccinno, V. Argentiero, Paolo Rizzotti, B. Tavolato,

Polyomavirus and related diseases

Lymphocyte subpopulations, T cell activation antigens, and serum levels of interleukin 2 (IL-2) and soluble IL-2 receptor (sIL2R), were studied in relapsing-remitting MS (RR-MS) patients before and after high-dose steroid therapy. Prior to therapy, a minority of patients showed increased HLA-DR antigen expression, and an increased number of CD16 + and CD19+ cells. Steroid treatment induced a significant increase in HLA-DR and CD 19 expression, a significant reduction in CD 16 +, CD57 +, and CD8 + CD57 + cells, and a slight, non-significant, decrease in IL-2 and sIL-2R levels and CD25 expression on CD4 + T lymphocytes.