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Molecular Epidemiology of Drug-Resistant Tuberculosis in Hungary

2006; American Society for Microbiology; Volume: 44; Issue: 11 Linguagem: Inglês

10.1128/jcm.01254-06

1098-660X

Csaba Ködmön, Stefan Niemann, J. Ágnes Lukács, Éva Sör, Sándor Dávid, Ákos Somoskövi,

Diagnosis and treatment of tuberculosis

Sixty-eight drug-resistant Mycobacterium tuberculosis isolates (44.2% of all resistant cases) were analyzed by IS6110 restriction fragment length polymorphism fingerprinting and spoligotyping to provide a deeper insight into the status of drug-resistant tuberculosis in Hungary. A total of 54.4% of the drug-resistant cases and 75% of the multidrug-resistant cases could be clustered. Analysis of the spoligotyping patterns of the strains revealed a high rate (66.2%) of infection by the Haarlem genotype, while none of the patients were infected by the Beijing genotype. The magnitude and the dynamics of drug-resistant tuberculosis are underestimated in Hungary.