Portal de Periódicos da CAPES

Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment

2012; Elsevier BV; Volume: 334; Issue: 2 Linguagem: Inglês

10.1016/j.canlet.2012.07.027

1872-7980

Elvin Blanco, Takafumi Sangai, Angela Hsiao, Silvia Ferrati, Litao Bai, Xuewu Liu, Funda Meric‐Bernstam, Mauro Ferrari,

Graphene and Nanomaterials Applications

Adequate drug delivery to tumors is hindered by barriers such as degradation and non-specific distribution. Nested incorporation of drug-containing nanoparticles within mesoporous silicon particles (MSVs), carriers rationally designed to enhance tumor transport, was hypothesized to result in pronounced and sustained antitumor efficacy. Paclitaxel (PTX)-containing poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-PCL) polymer micelles were favorably loaded within MSVs, after which drug release was significantly delayed. Antitumor efficacy analyses in mice bearing MDA-MB-468 breast tumors demonstrated significant tumor growth suppression following a single administration. Results highlight effective chemotherapeutic shuttling and site-specific controlled release afforded by MSVs, potentially translating towards improvements in patient outcomes and morbidity.