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Resveratrol as a new type of DNA-cleaving agent

1998; Elsevier BV; Volume: 8; Issue: 22 Linguagem: Inglês

10.1016/s0960-894x(98)00585-x

1464-3405

Kiyoshi Fukuhara, Naoki Miyata,

CRISPR and Genetic Engineering

The first demonstration of DNA cleavage by resveratrol ‘3,5,4′-trihydroxy-trans-stilbene’ is presented. Resveratrol mediated relaxation of pBR322 at micromolar concentrations in the presence of Cu2+. Evidence is provided that resveratrol is capable of binding to DNA, and that the Cu2+-dependent DNA damage is more likely caused by a copper-peroxide complex rather than by a freely diffusible oxygen species.