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Préparation de phénols tritiés —I Hydrogénolyse catalytique des derivés iodés de la thyronine, de la tyrosine et de l'Oestradiol

1962; Pergamon Press; Volume: 13; Issue: 10 Linguagem: Inglês

10.1016/0020-708x(62)90130-8

1878-1284

J. Núñez, C. Jacquemin, Jean Roche,

RNA modifications and cancer

A general method for tritiation of phenols by hydrogenolysis of their iodinated derivatives is described. The incorporation of the isotope is determined by the positions of the halogen atoms which are exclusively substituted by the tritium. Using 3:5 di-iodothyronine as starting material we have obtained 3-iodothyronine (H3-5), thyronine (H3-3:5) and their iodinated derivatives. After tritiation of 2:4 di-iodoestradiol we obtain H3-estradiol, while 3:5 diodotyrosine give rise to 3-iodotyrosine (H3-5) and tyrosine (H3-3,5). The method is not limited to the above-mentioned compounds but might also be used in the tritiation of a great number of other molecules of biological interest including peptides and smaller proteins.