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Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides

2010; Nature Portfolio; Volume: 17; Issue: 1 Linguagem: Inglês

10.1038/nm.2268

1546-170X

Jinyuan Zhou, E. Tryggestad, Zhibo Wen, Bachchu Lal, Tingting Zhou, Rachel Grossman, Silun Wang, Kun Yan, De-Xue Fu, Eric Ford, Betty Tyler, Jaishri O. Blakeley, John Laterra, Peter C.M. van Zijl,

Advanced MRI Techniques and Applications

A major problem in the clinical management of patients with brain tumors is distinguishing tumor recurrence from radiation-induced necrosis after brain tumor therapy. Zhou et al. use an MRI technique called amide proton transfer imaging to noninvasively differentiate between these two pathologies. The approach is successfully evaluated by comparing two orthotopic glioma models with a radiation necrosis model in rats. It remains difficult to distinguish tumor recurrence from radiation necrosis after brain tumor therapy. Here we show that these lesions can be distinguished using the amide proton transfer (APT) magnetic resonance imaging (MRI) signals of endogenous cellular proteins and peptides as an imaging biomarker. When comparing two models of orthotopic glioma (SF188/V+ glioma and 9L gliosarcoma) with a model of radiation necrosis in rats, we could clearly differentiate viable glioma (hyperintense) from radiation necrosis (hypointense to isointense) by APT MRI. When we irradiated rats with U87MG gliomas, the APT signals in the irradiated tumors had decreased substantially by 3 d and 6 d after radiation. The amide protons that can be detected by APT provide a unique and noninvasive MRI biomarker for distinguishing viable malignancy from radiation necrosis and predicting tumor response to therapy.