CuI-Catalyzed Amination of Arylhalides with Guanidines or Amidines: A Facile Synthesis of 1- H -2-Substituted Benzimidazoles
2009; American Chemical Society; Volume: 74; Issue: 15 Linguagem: Inglês
10.1021/jo900912h
ISSN1520-6904
AutoresXiaohu Deng, Heather McAllister, Neelakandha S. Mani,
Tópico(s)Chemical Synthesis and Analysis
ResumoCuI/L5 (N,N'-dimethylethylenediamine) proves to be an efficient catalyst system for the amination of arylhalides with guanidines. The same catalyst system is then successfully applied to the one-step synthesis of 1-H-2-amino-benzimidazoles through tandem aminations of 1,2-dihaloarenes in modest yields. This methodology is also applicable for the preparation of 1-H or 1-substutituted 2-aryl- or 2-alkyl-benzimidazoles.
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