Management of Acromegaly
1981; American College of Physicians; Volume: 95; Issue: 2 Linguagem: Inglês
10.7326/0003-4819-95-2-225
ISSN1539-3704
AutoresOlof H. Pearson, Baha Arafah, Jerald S. Brodkey,
Tópico(s)Myasthenia Gravis and Thymoma
ResumoEditorials1 August 1981Management of AcromegalyO. H. PEARSON, M.D., B. ARAFAH, M.D., J. BRODKEY, M.D.O. H. PEARSON, M.D.Search for more papers by this author, B. ARAFAH, M.D.Search for more papers by this author, J. BRODKEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-225 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcromegaly is a chronic disease not to be neglected. In addition to its metabolic abnormalities that are the consequence of excessive growth hormone secretion, neurologic sequelae can be caused by growth of the pituitary adenoma. Untreated acromegaly is associated with a decreased life expectancy (1). There is often a delay of several years in establishing the diagnosis because the telltale acral and facial changes occur gradually, and the patient and the immediate family interpret them as signs of aging. In treating this debilitating disease several options are currently available including surgical ablation of the pituitary tumor, conventional supervoltage or heavy...References1. WRIGHTHILLLOWRYFRASER ADCT. Mortality in acromegaly. Q J Med. 1970;39:1-16. MedlineGoogle Scholar2. EASTMANGORDENROTH RPJ. Conventional supervoltage irradiation is an effective treatment for acromegaly. J Clin Endocrinol Metab. 1979;48:931-40. CrossrefMedlineGoogle Scholar3. ALOIAARCHAMBEAU JJ. Hypopituitarism following pituitary irradiation for acromegaly. Horm Res. 1978;9:201-7. CrossrefMedlineGoogle Scholar4. LINFOOT J. Heavy ion therapy: alpha particle therapy of pituitary tumors. In: LINFOOT JA, ed. Recent Advances in the Diagnosis and Treatment of Pituitary Tumors. New York: Raven Press; 1979:245-67. Google Scholar5. KJELLBERGKLIMAN RB. Lifetime effectiveness—a system of therapy for pituitary adenomas, emphasizing Bragg peak proton hypophysectomy. In: LINFOOT JA, ed. Recent Advances in the Diagnosis and Treatment of Pituitary Tumors. New York: Raven Press; 1979:269-88. Google Scholar6. BESSERWASSTHORNER GJM. Bromocriptine in the medical management of acromegaly. Adv Biochem. 1980;23:191-8. Google Scholar7. WASSMOULTTHORNERDACIECHARLESWORTHJONES JPMJMA. Reduction of pituitary-tumour size in patients with prolactinomas and acromegaly treated with bromocriptine with or without radiotherapy. Lancet. 1979;2:66-9. CrossrefMedlineGoogle Scholar8. SALTIISTHAN IN. Bromocriptine fails to stop growth of eosinophilic adenomas in acromegaly. N Engl J Med. 1979;301:386. Letter. CrossrefMedlineGoogle Scholar9. LINDHOLMRIISHEDEVESTERGAARDHUMMERFABERHAGEN JJSLOC. No effect of bromocriptine in acromegaly: a controlled trial. N Engl J Med. 1981;304:1450-4. CrossrefMedlineGoogle Scholar10. HARDYSOMMAVEZINA JMJ. Treatment of acromegaly: radiation or surgery? In: MORLEY TP, ed. Current Controversies in Neurosurgery. Philadelphia: W. B. Saunders; 1976:377-84. Google Scholar11. FAGLIAPARACCHIFERRARIBECK-PECCOZ GACP. Evaluation of the results of trans-sphenoidal surgery in acromegaly by assessment of the growth hormone response to thyrotrophin-releasing hormone. Clin Endocrinol (Oxf). 1978;8:373-80. CrossrefMedlineGoogle Scholar12. ARAFAHBRODKEYKAUFMANVELASCOMANNIPEARSON BJBMAO. Transsphenoidal microsurgery in the treatment of acromegaly and gigantism. J Clin Endocrinol Metab. 1980;50:578-85. CrossrefMedlineGoogle Scholar13. ST GEORGE TUCKERGRUBBWIGANDWATLINGTONBLACKARDBECKER HSJCWD. The treatment of acromegaly by transsphenoidal surgery. Arch Intern Med. 1980;140:795-802. CrossrefMedlineGoogle Scholar14. CLEMMONSVAN DYKRIDGEWAYKLIMANKJELLBERGUNDERWOOD DJEBRL. Evaluation of acromegaly by measurement of somatomedin-C. N Engl J Med. 1979;301:1138-42. CrossrefMedlineGoogle Scholar15. SCHUSTERBANTLEOPPENHEIMERSELJESKOG LJJE. Acromegaly: reassessment of the long-term therapeutic effectiveness of transsphenoidal pituitary surgery. Ann Intern Med. 1981;95:172-4. LinkGoogle Scholar16. VELASCOSINDELYROESSMANN MSU. Reticulum stain for frozen-section diagnosis of pituitary adenomas. J Neurosurgery. 1977;46:548-50. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Medicine and Surgery Case Western Reserve University School of Medicine Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByQEvaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C measurement in acromegalyPOSTOPERATIVE PLASMA GH LEVELS AND RESTORATION OF GH DYNAMICS IN ACROMEGALIC PATIENTS SURGICALLY TREATED BY THE TRANSSPHENOIDAL APPROACHSyndrome of Inappropriate ADH SecretionThe AdenohypophysisTHE EFFECT OF A NEW ERGOLINE DERIVATIVE, CU 32-085, IN THE TREATMENT OF ACROMEGALY. A CONTROLLED STUDYAcromegaly and CancerIRWIN KLEIN, M.D.Recent Developments in Acromegaly: A Review 1Clinical use of pre- and postsurgical evaluation of abnormal GH responses in acromegalyColonie Polyps in Patients with AcromegalyIRWIN KLEIN, M.D., PARVEEN GULNAR, M.D., JUDITH S. GAVALER, B.S., VANTHIEL DAVID H., M.D. 1 August 1981Volume 95, Issue 2Page: 225-227KeywordsAcromegalyAgingGrowth hormoneLife expectancyPituitary tumors Issue Published: 1 August 1981 PDF DownloadLoading ...
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