A Comparative Study of Various Combinations of Ipratropium Bromide and Metaproterenol in Allergic Asthmatic Patients
1983; Elsevier BV; Volume: 83; Issue: 2 Linguagem: Inglês
10.1378/chest.83.2.208
ISSN1931-3543
AutoresI Bruderman, Razia Cohen-Aronovski, Joshua Smorzik,
Tópico(s)Respiratory and Cough-Related Research
ResumoThe bronchodilator effect of ipratropium bromide (IB) (Atrovent-Sch 1000), 40 μg inhaled, and metaproterenol (Met), 1.25 mg in various combinations, was compared in ten allergic asthmatic patients, aged 23 to 63 years. Six combinations were used at random in a double blind study. The following ventilatory functions—FVC, TGV, SGAW, FEV1, FEF 25-75, V ⋅ Emax , V ⋅ E 50 , V ⋅ E 25 , were measured at 30 min. intervals for the first two hours and at 60 minute intervals for the additional three hours. Inhalation of IB followed by Met resulted in additive bronchodilator effect that was significantly greater and longer than EB alone (p<0.05), Met alone (p<0.05), two consecutive inhalations of Met (p<0.05), or Met followed by IB (p<0.05). The bronchodilating effect of EB and Met after five hours was the same as IB after one hour. The bronchodilator effect of ipratropium bromide (IB) (Atrovent-Sch 1000), 40 μg inhaled, and metaproterenol (Met), 1.25 mg in various combinations, was compared in ten allergic asthmatic patients, aged 23 to 63 years. Six combinations were used at random in a double blind study. The following ventilatory functions—FVC, TGV, SGAW, FEV1, FEF 25-75, V ⋅ Emax , V ⋅ E 50 , V ⋅ E 25 , were measured at 30 min. intervals for the first two hours and at 60 minute intervals for the additional three hours. Inhalation of IB followed by Met resulted in additive bronchodilator effect that was significantly greater and longer than EB alone (p<0.05), Met alone (p<0.05), two consecutive inhalations of Met (p<0.05), or Met followed by IB (p<0.05). The bronchodilating effect of EB and Met after five hours was the same as IB after one hour.
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