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Effect of Cimetidine on the Pharmacokinetics of Quinidine and Lidocaine in the Rat

1983; Elsevier BV; Volume: 72; Issue: 7 Linguagem: Inglês

10.1002/jps.2600720730

1520-6017

Richard J. Fruncillox, G. John Digregorio, Adam Soll,

Ion Transport and Channel Regulation

Because of previously reported drug interactions involving cimetidine and liver-metabolized drugs, the intravenous pharmacokinetics of quinidine (25 mg/kg) and lidocaine (15 mg/kg) were investigated in anesthetized rats pretreated with a single intraperitoneal dose of cimetidine (60 mg/kg) and compared with saline pretreated controls. Significant reductions of 35 and 23% in the respective total clearances of quinidine and lidocaine were observed in the presence of cimetidine. The quinidine volume of distribution was significantly decreased in the cimetidine-treated rats, while the lidocaine volume of distribution was not altered significantly. There was no significant change in the elimination half-life for either drug in the presence of cimetidine. These results suggest cautious use of quinidine or lidocaine when cimetidine is prescribed concurrently.