Differential immunogenicity of HLA mismatches: HLA-A2 versus HLA-A28
2003; Wolters Kluwer; Volume: 75; Issue: 3 Linguagem: Inglês
10.1097/01.tp.0000044456.51462.e2
ISSN1534-6080
AutoresMarlies K.A. Dankers, Dave L. Roelen, Ellen M. W. van der Meer‐Prins, Peter de Lange, Nelleke Korfage, Jacqueline M. Smits, Guido G. Persijn, Ken I. Welsh, Ilias I.N. Doxiadis, Frans H.J. Claas,
Tópico(s)Reproductive System and Pregnancy
ResumoThe immunogenicity of human leukocyte antigen (HLA)-A2 versus HLA-A28 was analyzed by antibody production, cytotoxic T-lymphocyte (CTL) induction, and graft survival. We observed that an HLA-A2 mismatched child in HLA-A28+ women leads to HLA-A2 specific antibodies in 32% of the women (n=31), whereas in the case of an HLA-A28+ child and HLA-A2+ women (n=30), no HLA-A28 specific antibodies were found (P <0.002). Also, the CTL precursor frequencies were significantly lower against HLA-A28 compared with CTLp frequencies against HLA-A2 (P =0.012). Finally, the kidney graft survival was slightly better in HLA-A2 positive recipients transplanted with HLA-A28 mismatches. We can conclude that single HLA-A28 mismatches are less immunogenic in HLA-A2 individuals compared with single HLA-A2 mismatches in HLA-A28 individuals, which is probably because the mismatched epitopes on the HLA-A2 molecule are unique epitopes, whereas the mismatched epitopes on HLA-A28 are shared by other HLA-A and HLA-B molecules.
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