Discriminative Hypomania Checklist-32 Factors in Unipolar and Bipolar Major Depressive Patients
2012; Karger Publishers; Volume: 45; Issue: 6 Linguagem: Inglês
10.1159/000338047
ISSN1423-033X
AutoresGiulio Perugi, Michele Fornaro, Icro Maremmani, Pier Luigi Canonico, Paolo Carbonatto, Claudio Mencacci, Giovanni Muscettola, Luca Pani, Riccardo Torta, Claudio Vampini, Fabio Parazzini, Arina Dumitriu, Jules Angst,
Tópico(s)Stuttering Research and Treatment
Resumo<b><i>Background:</i></b> Although manic or hypomanic episodes define bipolar disorder (BD), most patients show a predominance of depressive symptomatology, often associated with delayed or disregarded BD diagnosis. The Hypomania Checklist-32 (HCL-32) has therefore been developed and tested internationally to facilitate BD recognition. <b><i>Sampling and</i></b><b><i>Methods:</i></b> Five hundred seventy-one (563 eligible) patients diagnosed with a major depressive episode according to DSM-IV criteria were consecutively enrolled in a cross-sectional, multicenter, observational study (Come To Me). Lifetime manic or hypomanic features were assessed by the HCL-32, and severity of depressive and anxious symptomatology was assessed using the Zung’s self-report questionnaires for depression and anxiety. <b><i>Results</i></b>: Among the patients diagnosed with BD (n = 119), either type I or type II, the occurrence of (hypo)manic symptoms was significantly higher compared to major depressive disorder (MDD) symptoms according to HCL-32 total and subscale scores obtained using a score of 14, which ensured an optimal discrimination between BD and MDD with a sensitivity of 0.85 and a specificity of 0.78. <b><i>Conclusions</i></b>: Although some false positives might occur, the HCL-32 was confirmed to be a useful instrument in the detection of past hypomania in MDD patients, finally contributing to proper therapeutic choices.
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