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C-Terminal Modifications of Histidyl- N -benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice

1997; American Chemical Society; Volume: 40; Issue: 21 Linguagem: Inglês

10.1021/jm970470c

1520-4804

Dennis J. McNamara, Ellen M. Dobrusin, Daniele M. Leonard, Kevon R. Shuler, James S. Kaltenbronn, John Quin, Scott K. Bur, C. Thomas, Annette M. Doherty, Jeffrey D. Scholten, Karen K. Zimmerman, Barbara S. Gibbs, Richard Gowan, Michael P. Latash, Wilbur R. Leopold, Sally Przybranowski, Judith S. Sebolt‐Leopold,

Synthesis and Reactivity of Heterocycles

ADVERTISEMENT RETURN TO ISSUELetterNEXTC-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in MiceDennis J. McNamara, Ellen Dobrusin, Daniele M. Leonard, Kevon R. Shuler, James S. Kaltenbronn, John Quin, Scott Bur, Charles E. Thomas, Annette M. Doherty, Jeffrey D. Scholten, Karen K. Zimmerman, Barbara S. Gibbs, Richard C. Gowan, Michael P. Latash, Wilbur R. Leopold, Sally A. Przybranowski, and Judith S. Sebolt-LeopoldView Author Information Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48105 Cite this: J. Med. Chem. 1997, 40, 21, 3319–3322Publication Date (Web):October 10, 1997Publication History Received18 July 1997Published online10 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/jm970470chttps://doi.org/10.1021/jm970470crapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views159Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anticancer activity,Inhibition,Monomers,Peptides and proteins,Rodent models Get e-Alerts