Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Synthesis and biological evaluation of some 6-substituted purines

2006; Elsevier BV; Volume: 42; Issue: 4 Linguagem: Inglês

10.1016/j.ejmech.2006.10.014

1768-3254

Fernanda Gambogi Braga, Elaine Soares Coimbra, Magnum de Oliveira Matos, Arturene Maria Lino Carmo, Marisa Damato Cancio, Adilson David da Silva,

Synthesis and biological activity

We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6-substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3′-chloropropylthio)purine 2 (D.A. Benson, I. Karsch-Mizrachi, D.J. Lipman, J. Ostell, B.A. Rapp, D.L. Wheeler, Genbank. Nucleic Acids Res. 28 (2000) 15–18; E.V. Aleksandrova, P.M.I.E. Valashek, J. Med. Pharm. Chem. 35 (2001) 172–173), 6-(3′-(thioethylamine)propylthio)purine 5, 6-(α-aceticacidthio)purine 7 and 6-(6′-deoxy-1′-O-methyl-β-d-ribofuranose)purine 14 with an IC50 = 50, 50, 39 and 29 μM, respectively.