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Racial/ethnic differences in drug disposition and response: Review of recently approved drugs

2015; Wiley; Volume: 97; Issue: 3 Linguagem: Inglês

10.1002/cpt.61

1532-6535

Anuradha Ramamoorthy, MA Pacanowski, Jonca Bull, L Zhang,

HIV/AIDS drug development and treatment

Race and ethnicity can contribute to interindividual differences in drug exposure and/or response, which may alter risk–benefit in certain populations. Approximately one‐fifth of new drugs approved in the past 6 years demonstrated differences in exposure and/or response across racial/ethnic groups, translating to population‐specific prescribing recommendations in a few cases. When data from diverse populations were lacking, additional postmarketing studies were recommended. In this review we highlight several cases where race/ethnicity was central to regulatory decision‐making.